| Jornada 1 | 03-09-2000 | SEVILLA | 2 | MURCIA | 1 |
| Jornada 2 | 10-09-2000 | SALAMANCA | 0 | SEVILLA | 1 |
| Jornada 3 | 17-09-2000 | ELCHE | 1 | SEVILLA | 2 |
| Jornada 4 | 24-09-2000 | SEVILLA | 2 | LLEIDA | 0 |
| Jornada 5 | 01-10-2000 | LEGANES | 1 | SEVILLA | 1 |
| Jornada 6 | 08-10-2000 | SEVILLA | 1 | ALBACETE | 0 |
| Jornada 7 | 15-10-2000 | SPORTING GIJON | 3 | SEVILLA | 0 |
| Jornada 8 | 22-10-2000 | SEVILLA | 1 | GETAFE | 1 |
| Jornada 9 | 29-10-2000 | LEVANTE | 2 | SEVILLA | 0 |
| Jornada 10 | 01-11-2000 | SEVILLA | 0 | RECREATIVO | 0 |
| Jornada 11 | 05-11-2000 | REAL JAEN | 2 | SEVILLA | 1 |
| Jornada 12 | 12-11-2000 | SEVILLA | 4 | COMPOSTELA | 0 |
| Jornada 13 | 19-11-2000 | BETIS | 1 | SEVILLA | 3 |
| Jornada 14 | 26-11-2000 | SEVILLA | 3 | RAC.FERROL | 0 |
| Jornada 15 | 03-12-2000 | BADAJOZ | 2 | SEVILLA | 0 |
| Jornada 16 | 10-12-2000 | SEVILLA | 3 | ATLETICO MADRID | 1 |
| Jornada 17 | 17-12-2000 | CORDOBA | 0 | SEVILLA | 1 |
| Jornada 18 | 20-12-2000 | SEVILLA | 2 | UNIV.PALMAS | 2 |
| Jornada 19 | 07-01-2001 | TENERIFE | 1 | SEVILLA | 2 |
| Jornada 20 | 14-01-2001 | SEVILLA | 3 | EXTREMADURA | 0 |
| Jornada 21 | 21-01-2001 | EIBAR | 1 | SEVILLA | 0 |
| Jornada 22 | 28-01-2001 | MURCIA | 1 | SEVILLA | 1 |
| Jornada 23 | 04-02-2001 | SEVILLA | 2 | SALAMANCA | 0 |
| Jornada 24 | 11-02-2001 | SEVILLA | 1 | ELCHE | 1 |
| Jornada 25 | 18-02-2001 | LLEIDA | 0 | SEVILLA | 1 |
| Jornada 26 | 25-02-2001 | SEVILLA | 4 | LEGANES | 2 |
| Jornada 27 | 04-03-2001 | ALBACETE | 2 | SEVILLA | 1 |
| Jornada 28 | 11-03-2001 | SEVILLA | 1 | SPORTING GIJON | 1 |
| Jornada 29 | 18-03-2001 | GETAFE | 0 | SEVILLA | 1 |
| Jornada 30 | 25-03-2001 | SEVILLA | 3 | LEVANTE | 2 |
| Jornada 31 | 01-04-2001 | RECREATIVO | 1 | SEVILLA | 1 |
| Jornada 32 | 08-04-2001 | SEVILLA | 0 | REAL JAEN | 1 |
| Jornada 33 | 15-04-2001 | COMPOSTELA | 0 | SEVILLA | 2 |
| Jornada 34 | 22-04-2001 | SEVILLA | 1 | BETIS | 1 |
| Jornada 35 | 29-04-2001 | RAC.FERROL | 1 | SEVILLA | 1 |
| Jornada 36 | 06-05-2001 | SEVILLA | 5 | BADAJOZ | 2 |
| Jornada 37 | 13-05-2001 | ATLETICO MADRID | 2 | SEVILLA | 0 |
| Jornada 38 | 20-05-2001 | SEVILLA | 2 | CORDOBA | 0 |
| Jornada 39 | 27-05-2001 | UNIV.PALMAS | 1 | SEVILLA | 3 |
| Jornada 40 | 03-06-2001 | SEVILLA | 1 | TENERIFE | 0 |
| Jornada 41 | 10-06-2001 | EXTREMADURA | 1 | SEVILLA | 1 |
| Jornada 42 | 17-06-2001 | SEVILLA | 2 | EIBAR | 1 |