| Jornada 1 | 10-09-2000 | REAL SOCIEDAD | 2 | RAC.SANTANDER | 2 |
| Jornada 2 | 17-09-2000 | RAC.SANTANDER | 0 | DEPORTIVO | 3 |
| Jornada 3 | 24-09-2000 | FC BARCELONA | 3 | RAC.SANTANDER | 1 |
| Jornada 4 | 01-10-2000 | RAC.SANTANDER | 0 | REAL MADRID | 0 |
| Jornada 5 | 15-10-2000 | MALLORCA | 2 | RAC.SANTANDER | 1 |
| Jornada 6 | 22-10-2000 | RAC.SANTANDER | 4 | NUMANCIA | 2 |
| Jornada 7 | 29-10-2000 | LAS PALMAS | 2 | RAC.SANTANDER | 1 |
| Jornada 8 | 01-11-2000 | RAC.SANTANDER | 3 | VILLARREAL | 1 |
| Jornada 9 | 05-11-2000 | ZARAGOZA | 2 | RAC.SANTANDER | 0 |
| Jornada 10 | 12-11-2000 | RAC.SANTANDER | 0 | OSASUNA | 0 |
| Jornada 11 | 19-11-2000 | CELTA | 1 | RAC.SANTANDER | 1 |
| Jornada 12 | 26-11-2000 | RAC.SANTANDER | 1 | ESPANYOL | 2 |
| Jornada 13 | 03-12-2000 | RAYO VALLEC. | 4 | RAC.SANTANDER | 1 |
| Jornada 14 | 10-12-2000 | RAC.SANTANDER | 2 | ALAVES | 1 |
| Jornada 15 | 17-12-2000 | OVIEDO | 1 | RAC.SANTANDER | 0 |
| Jornada 16 | 20-12-2000 | RAC.SANTANDER | 2 | VALLADOLID | 2 |
| Jornada 17 | 07-01-2001 | VALENCIA | 1 | RAC.SANTANDER | 0 |
| Jornada 18 | 14-01-2001 | RAC.SANTANDER | 0 | MALAGA | 1 |
| Jornada 19 | 21-01-2001 | ATHLETIC BILBAO | 3 | RAC.SANTANDER | 1 |
| Jornada 20 | 28-01-2001 | RAC.SANTANDER | 1 | REAL SOCIEDAD | 4 |
| Jornada 21 | 04-02-2001 | DEPORTIVO | 2 | RAC.SANTANDER | 1 |
| Jornada 22 | 11-02-2001 | RAC.SANTANDER | 4 | FC BARCELONA | 0 |
| Jornada 23 | 18-02-2001 | REAL MADRID | 1 | RAC.SANTANDER | 0 |
| Jornada 24 | 25-02-2001 | RAC.SANTANDER | 2 | MALLORCA | 1 |
| Jornada 25 | 04-03-2001 | NUMANCIA | 1 | RAC.SANTANDER | 0 |
| Jornada 26 | 11-03-2001 | RAC.SANTANDER | 2 | LAS PALMAS | 1 |
| Jornada 27 | 18-03-2001 | VILLARREAL | 4 | RAC.SANTANDER | 2 |
| Jornada 28 | 01-04-2001 | RAC.SANTANDER | 2 | ZARAGOZA | 1 |
| Jornada 29 | 08-04-2001 | OSASUNA | 1 | RAC.SANTANDER | 1 |
| Jornada 30 | 15-04-2001 | RAC.SANTANDER | 3 | CELTA | 0 |
| Jornada 31 | 22-04-2001 | ESPANYOL | 3 | RAC.SANTANDER | 0 |
| Jornada 32 | 29-04-2001 | RAC.SANTANDER | 1 | RAYO VALLEC. | 1 |
| Jornada 33 | 06-05-2001 | ALAVES | 5 | RAC.SANTANDER | 1 |
| Jornada 34 | 13-05-2001 | RAC.SANTANDER | 2 | OVIEDO | 0 |
| Jornada 35 | 20-05-2001 | VALLADOLID | 1 | RAC.SANTANDER | 1 |
| Jornada 36 | 27-05-2001 | RAC.SANTANDER | 1 | VALENCIA | 1 |
| Jornada 37 | 10-06-2001 | MALAGA | 2 | RAC.SANTANDER | 1 |
| Jornada 38 | 17-06-2001 | RAC.SANTANDER | 3 | ATHLETIC BILBAO | 0 |